Hussey’s wife has given birth to the couple’s fourth child prematurely, and 37-year-old Hussey has chosen to stay home to be with his family.
He will be replaced by Peter Forrest, who played against the West Indies in their recent ODI series, scoring a half-century.
Hussey’s statement read: “Due to our baby being born three months early, it is important for the family for me to be here at this time.
“It is always difficult to miss any tour for Australia and I thank CA for their understanding of our family’s situation.”
Hussey has played 181 ODI’s for Australia. The first ODI will be at Lord’s on 29 June.